LDN-27219 protein kinase targeting Things To Know Before You Buy
A single specifically intriguing compound is LDN-27219. Whilst most tTG inhibitors are created to bind into the protein crosslinking Energetic web site, LDN-27219 as an alternative binds towards the nucleotide binding pocket of your enzyme while it really is in its closed-condition conformation, and stabilizes that conformation to stop crosslinking